He planned to use it to change the future this saw the first steps of the great doctor's descent into madness. Over time however, he became obsessed with his research, as his experiments began taking gruesome and unethical turns. Several years before the Curien Mansion case, in an effort to discover the cure to his son Daniel's terminal illness, he began researching the nature of life and death. Curien's motives are explored through flashbacks.

Notorious for his role in the creation of the original undead horde, Dr. Thomas' 19-year-old daughter, Lisa, and Rogan's former partner, G, travel there two weeks later with shotguns in hand after contact with him is mysteriously lost. Ex-AMS agent Thomas Rogan and his team of highly trained commandos investigate the EFI Research Facility, which may be linked to the disaster.

Set in post-apocalyptic 2019, civilization has long since collapsed. The game's main protagonist is Lisa Rogan, daughter of Thomas Rogan and newcoming Dan Taylor, the first game's main character, and players control Lisa, G, or Daniel Curien The game continues the story of the previous games and introduces new gameplay concepts such as story branching. It was later ported to the Xbox in 2003, Microsoft Windows in 2005, the Wii in 2008 in a compilation with The House of the Dead 2, and PlayStation 3 in 2012 with PlayStation Move support. The House of the Dead III is a 2002 light gun arcade game with a horror zombie-survival theme, and the third installment to the House of the Dead series of video games, developed by Wow Entertainment and Sega.

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